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According to the Pocket Manual of Therapy, the universal clinical scenario has evolved from topical treatments to precision biotechnological therapies

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In bypass, pyruvate is first converted to ACH by pyruvate decarboxylase (Pdc) and then ACH is metabolized either to acetate by aldehyde dehydrogenases (Ald) or turned into ethanol by alcohol dehydrogenase (Adh) enzymes

In summary, recent studies indicate a possible connection between TMAO and AKI, with elevated TMAO levels observed in AKI patients

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